Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nr5a1  nuclear receptor subfamily 5, group A, member 1   (Synonyms: Ad4BP, adrenal 4-binding protein, ELP, Ftzf1, Ftz-F1, SF1, SF-1, steroidogenic factor 1)
Results	Reference
1	J:311885 Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A, Pu WT, Hohenstein P, Martinez A, Schedl A, WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14;27(1):5-18
1	J:153050 Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A, Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol. 2009 Sep;7(9):e1000196
1	J:237198 Burton RF, Relationships among fat mass, fat-free mass and height in adults: A new method of statistical analysis applied to NHANES data. Am J Hum Biol. 2017 May 6;29(3)
1	J:189064 Chassot AA, Bradford ST, Auguste A, Gregoire EP, Pailhoux E, de Rooij DG, Schedl A, Chaboissier MC, WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad. Development. 2012 Dec;139(23):4461-72
1	J:269807 Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA, An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 6;10(1):62-74
1	J:171480 DeFalco T, Takahashi S, Capel B, Two distinct origins for Leydig cell progenitors in the fetal testis. Dev Biol. 2011 Apr 1;352(1):14-26
1	J:204550 Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R, Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
1*	J:116501 Fukami M, Wada Y, Miyabayashi K, Nishino I, Hasegawa T, Camerino G, Kretz C, Buj-Bello A, Laporte J, Yamada G, Morohashi K, Ogata T, CXorf6 is a causative gene for hypospadias. Nat Genet. 2006 Dec;38(12):1369-71
1	J:244596 Furlan A, Dyachuk V, Kastriti ME, Calvo-Enrique L, Abdo H, Hadjab S, Chontorotzea T, Akkuratova N, Usoskin D, Kamenev D, Petersen J, Sunadome K, Memic F, Marklund U, Fried K, Topilko P, Lallemend F, Kharchenko PV, Ernfors P, Adameyko I, Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. Science. 2017 Jul 07;357(6346)
1	J:315113 Hafner R, Bohnenpoll T, Rudat C, Schultheiss TM, Kispert A, Fgfr2 is required for the expansion of the early adrenocortical primordium. Mol Cell Endocrinol. 2015 Sep 15;413:168-77
1	J:138181 Ikeda Y, Tanaka H, Esaki M, Effects of gestational diethylstilbestrol treatment on male and female gonads during early embryonic development. Endocrinology. 2008 Aug;149(8):3970-9
1	J:181719 Katoh-Fukui Y, Miyabayashi K, Komatsu T, Owaki A, Baba T, Shima Y, Kidokoro T, Kanai Y, Schedl A, Wilhelm D, Koopman P, Okuno Y, Morohashi K, Cbx2, a polycomb group gene, is required for Sry gene expression in mice. Endocrinology. 2012 Feb;153(2):913-24
1	J:155826 King P, Paul A, Laufer E, Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21185-90
1	J:268317 Kumar DL, DeFalco T, A perivascular niche for multipotent progenitors in the fetal testis. Nat Commun. 2018 Oct 30;9(1):4519
1	J:200895 Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, Tachibana M, Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. Science. 2013 Sep 6;341(6150):1106-9
1	J:168643 Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi K, Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads. Endocrinology. 2010 Dec;151(12):5893-904
1	J:306212 Ma T, Wong SZH, Lee B, Ming GL, Song H, Decoding neuronal composition and ontogeny of individual hypothalamic nuclei. Neuron. 2021 Apr 7;109(7):1150-1167.e6
1	J:97451 Matoba S, Kanai Y, Kidokoro T, Kanai-Azuma M, Kawakami H, Hayashi Y, Kurohmaru M, A novel Sry-downstream cellular event which preserves the readily available energy source of glycogen in mouse sex differentiation. J Cell Sci. 2005 Apr 1;118(Pt 7):1449-59
1	J:222626 McClelland KS, Bell K, Larney C, Harley VR, Sinclair AH, Oshlack A, Koopman P, Bowles J, Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. Biol Reprod. 2015 Jun;92(6):145
1	J:225050 Miyabayashi K, Katoh-Fukui Y, Ogawa H, Baba T, Shima Y, Sugiyama N, Kitamura K, Morohashi K, Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells. PLoS One. 2013;8(6):e68050
1	J:297093 Miyawaki S, Kuroki S, Maeda R, Okashita N, Koopman P, Tachibana M, The mouse Sry locus harbors a cryptic exon that is essential for male sex determination. Science. 2020 Oct 2;370(6512):121-124
1*	J:334115 Neirijnck Y, Sararols P, Kuhne F, Mayere C, Weerasinghe Arachchige LC, Regard V, Nef S, Schedl A, Single-cell transcriptomic profiling redefines the origin and specification of early adrenogonadal progenitors. Cell Rep. 2023 Feb 28;42(3):112191
1	J:300503 Nicol B, Rodriguez K, Yao HH, Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice. Biol Reprod. 2020 Oct 29;103(5):966-977
1	J:88700 Odet F, Guyot R, Leduque P, Le Magueresse-Battistoni B, Evidence for similar expression of protein C inhibitor and the urokinase-type plasminogen activator system during mouse testis development. Endocrinology. 2004 Mar;145(3):1481-9
1*	J:284860 Okashita N, Kuroki S, Maeda R, Tachibana M, TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression. Sci Rep. 2019 Sep 17;9(1):13462
1	J:338020 Okashita N, Maeda R, Tachibana M, CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2221499120
1	J:322444 Omotehara T, Nakata H, Itoh M, Three-dimensional analysis of mesonephric tubules remodeling into efferent tubules in the male mouse embryo. Dev Dyn. 2022 Mar;251(3):513-524
1*	J:289913 Omotehara T, Wu X, Kuramasu M, Itoh M, Connection between seminiferous tubules and epididymal duct is originally induced before sex differentiation in a sex-independent manner. Dev Dyn. 2020 Jun;249(6):754-764
1	J:197599 Pitetti JL, Calvel P, Romero Y, Conne B, Truong V, Papaioannou MD, Schaad O, Docquier M, Herrera PL, Wilhelm D, Nef S, Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 2013;9(1):e1003160
1	J:185348 Saito D, Takase Y, Murai H, Takahashi Y, The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification. Science. 2012 Jun 22;336(6088):1578-81
1	J:306614 Sasaki K, Oguchi A, Cheng K, Murakawa Y, Okamoto I, Ohta H, Yabuta Y, Iwatani C, Tsuchiya H, Yamamoto T, Seita Y, Saitou M, The embryonic ontogeny of the gonadal somatic cells in mice and monkeys. Cell Rep. 2021 May 4;35(5):109075
1	J:92065 Schmahl J, Kim Y, Colvin JS, Ornitz DM, Capel B, Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development. 2004 Aug;131(15):3627-36
1	J:325558 Torres-Cano A, Portella-Fortuny R, Muller-Sanchez C, Porras-Marfil S, Ramiro-Pareta M, Chau YY, Reina M, Soriano FX, Martinez-Estrada OM, Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice. PLoS Genet. 2022 Jun;18(6):e1010240
1	J:228533 Umemura Y, Miyamoto R, Hashimoto R, Kinoshita K, Omotehara T, Nagahara D, Hirano T, Kubota N, Minami K, Yanai S, Masuda N, Yuasa H, Mantani Y, Matsuo E, Yokoyama T, Kitagawa H, Hoshi N, Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XY(POS) mice. J Vet Med Sci. 2016 Jan 1;77(12):1587-98
1	J:135126 Val P, Martinez-Barbera JP, Swain A, Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development. 2007 Jun;134(12):2349-58
1	J:77996 Wilhelm D, Englert C, The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1. Genes Dev. 2002 Jul 15;16(14):1839-51
1*	J:149243 Wilhelm D, Washburn LL, Truong V, Fellous M, Eicher EM, Koopman P, Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. Mech Dev. 2009 May-Jun;126(5-6):324-36
1	J:245934 Xing Y, Morohashi KI, Ingraham HA, Hammer GD, Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1. Development. 2017 Oct 15;144(20):3798-3807
1	J:319845 Yu H, Rubinstein M, Low MJ, Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes. Elife. 2022 Jan 19;11:e72883
1	J:152917 Zubair M, Oka S, Parker KL, Morohashi K, Transgenic expression of Ad4BP/SF-1 in fetal adrenal progenitor cells leads to ectopic adrenal formation. Mol Endocrinol. 2009 Oct;23(10):1657-67